Phenobarbitone Adverse Effect: Due to the hepatic microsomal induction the AUC of Montelukast is decreased by concomitant administration of Phenobarbitone Clinical Management: Monitor for the therapeutic effects and adjust the dose if required.
RifampicinAdverse Effect: Due to the hepatic microsomal induction the AUC of Montelukast is decreased by concomitant administration of Rifampicin Clinical Management: Monitor for the therapeutic effects and adjust the dose if required. |